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ALPHA-2 adrenergic receptor blockade

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Cells1

Outcomes

1

Glu-stimulated norepinephrine release

upin rats1

1 study

  1. ALPHA-2 adrenergic receptor blockade improves Glu-stimulated norepinephrine release in rats (to the levels of young controls).

    “blockade of alpha-2 adrenergic receptors fully restores Glu-stimulated NE release to the levels of young controls”

    Animalscerebral cortex

    Pharmacological target sites for restoration of age-associated deficits in NMDA receptor-mediated norepinephrine release in brain

    Journal of neurochemistryDec 10, 2024

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