BMC Biology
Aged tissue scaffolds promote breast tumor growth in mice
Human breast cancer cells on scaffolds from mice aged 24–48 months formed larger tumors in young mice than cells on scaffolds from mice aged 2–4 months.Human breast cancer cells on scaffolds from mice aged 24–48 months formed larger tumors in young mice than cells on scaffolds from mice aged 2–4 months.
Mouse studyMechanisms
Who was studiedYoung Rag1−/− mice, 6 weeks, against tumors on young scaffolds
What changedTumors on aged scaffolds were larger: 327 ± 132 mm versus 162 ± 60 mm on young scaffolds
The catchFollow-up lasted 6 weeks, missing the gradual matrix remodeling of chronic aging