ACACETIN-EMCH-D6
ACACETIN-EMCH-D6 has been studied in 1 paper since 2022: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Dec 20, 2022: “An Acid-Sensitive Bone Targeting Delivery System Carrying Acacetin Prevents Osteoporosis in Ovariectomized Mice”.
1 paper studies it3 findingsUpdated
See all 1 papers on ACACETIN-EMCH-D6
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funder: National Natural Science Foundation of China
- Animals1
What did studies of ACACETIN-EMCH-D6 find?
3Studies of ACACETIN-EMCH-D6 measured 3 outcomes: autophagy, trabecular bone mass and Osteoclast formation.
Autophagy
downin mice1
1 study
Autophagy
downin mice1
ACACETIN-EMCH-D6 inhibits autophagy in mice (targeted delivery to bone resorption sites via PI3K/AKT/mTOR activation).
“targeted delivery of acacetin to the bone resorption sites by Acacetin-EMCH-D6 inhibited autophagy through activating PI3K/AKT/mTOR pathway in osteoclasts”
Animalstargeted delivery to bone resorption sites via PI3K/AKT/mTOR activationacid-sensitive bone-targeting delivery systemosteoclasts
Pharmaceuticals (Basel, Switzerland)
Trabecular bone mass
upin mice1
1 study
Trabecular bone mass
upin mice1
ACACETIN-EMCH-D6 increases trabecular bone mass in ovariectomy-induced osteoporosis mice.
“treatment with Acacetin-EMCH-D6 inhibited osteoclast formation and increased trabecular bone mass”
Animalsin ovariectomy-induced osteoporosis miceacid-sensitive bone-targeting delivery systemtrabecular bonefemales
Pharmaceuticals (Basel, Switzerland)
Osteoclast formation
downin mice1
1 study
Osteoclast formation
downin mice1
ACACETIN-EMCH-D6 decreases osteoclast formation in ovariectomy-induced osteoporosis mice.
“treatment with Acacetin-EMCH-D6 inhibited osteoclast formation and increased trabecular bone mass”
Animalsin ovariectomy-induced osteoporosis miceacid-sensitive bone-targeting delivery systemosteoclastsfemales
Pharmaceuticals (Basel, Switzerland)