AgingResearch.NewsJoin free

3-hydroxyphenylacetic acid

Intervention

1 paper2 findings

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Beijing Nova Program and 5 more
  • Animals1

Outcomes

2

Ferroptosis

downin mice1

1 study

  1. 3-hydroxyphenylacetic acid inhibits ferroptosis in mice.

    “3-HPAA induced an upregulation of GPX4, thereby restraining ferroptosis and restoring spermatogenesis.”

    Animals

    The gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis

    MicrobiomeSep 27, 2023

More on Ferroptosis

Spermatogenesis

upin mice1

1 study

  1. 3-hydroxyphenylacetic acid improves spermatogenesis in mice.

    “3-HPAA treatment resulted in an improvement of spermatogenesis in old mice.”

    Animals

    The gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis

    MicrobiomeSep 27, 2023

Latest

Related