2-acetylaminofluorene

1. 2-acetylaminofluorene induces karyomegaly in mice.

   “old mice were sensitive to induction of liver karyomegaly and cytoplasmic and nuclear inclusions, while young and mid-aged mice were resistant to this influence”

   Animalsliver500 ppm6 mofemales

   Age-dependent responses to 2-acetylaminofluorene in BALB/c female mice

   Journal of toxicology and environmental health·1 Jan 1987

1. 2-acetylaminofluorene increases urinary bladder hyperplasia in mice.

   “In all three replicates urinary bladder hyperplasia was less severe when young mice were treated than when mid-aged or old mice were treated.”

   Animalsin female mice treated for 6 mourinary bladder500 ppm6 mofemales

   Age-dependent responses to 2-acetylaminofluorene in BALB/c female mice

   Journal of toxicology and environmental health·1 Jan 1987

1. 2-acetylaminofluorene raises the risk of mammary tumors in mice.

   “sensitivity to the induction of mammary tumorigenesis by 2-AAF increased with the age of mice at the time of treatment”

   Animalswith increasing age at treatmentmammary gland500 ppm6 mofemales

   Age-dependent responses to 2-acetylaminofluorene in BALB/c female mice

   Journal of toxicology and environmental health·1 Jan 1987

More on Mammary tumors