18f-synvest-1

18f-synvest-1 has been studied in 1 paper since 2026: 1 observational study in people; 1 in the past year. The newest paper, Jun 1, 2026: “Quantification of ¹⁸F-SynVesT-1 binding in healthy aging and head-to-head comparison with ¹¹C-UCB-J”.

Intervention

1 paper studies it4 findingsUpdated

PubChem

“we found a strong inverse association between [18F]SynVesT-1 PET uptake and amyloid β and tau PET deposition.”
Imaging Synaptic Density in Aging and Alzheimer Disease with [¹⁸F]SynVesT-1Journal of nuclear medicine : official publication, Society of Nuclear Medicine2025doi:10.2967/jnumed.124.269005

None of its findings points the other way.

  • 1 lab in 1 country
  • Funder: National Institute on Aging
  • 4 of 4 findings with company ties
  • Humans1

What is 18f-synvest-1 linked with?

2

Studies link 18f-synvest-1 with 2 measures, most often cognitive function (2 studies) and amyloid β and tau PET deposition (2).

Cognitive function

upin humans2

2 studies
  1. 18f-synvest-1 is associated with cognitive function in humans.

    “individuals with a lower temporal gray matter volume but higher temporal [18F]SynVesT-1 PET uptake show preserved performance on the mini-mental state examination.”

    Humansin individuals with lower temporal gray matter volumetemporal gray matter

    Imaging Synaptic Density in Aging and Alzheimer Disease with [¹⁸F]SynVesT-1

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

  2. 18f-synvest-1 is associated with cognitive function in humans.

    “individuals with lower temporal grey matter volume but higher temporal [ 18 F]-SynVesT-1 PET uptake show preserved performance on the MMSE”

    Humansin individuals with lower temporal grey matter volumebrain

    Imaging synaptic density in ageing and Alzheimer’s Disease with [ 18 F]-SynVesT-1

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

Amyloid β and tau PET deposition

downin humans2

2 studies
  1. 18f-synvest-1 is associated with amyloid β and tau PET deposition in humans.

    “we found a strong inverse association between [18F]SynVesT-1 PET uptake and amyloid β and tau PET deposition.”

    Humansbrain

    Imaging Synaptic Density in Aging and Alzheimer Disease with [¹⁸F]SynVesT-1

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

  2. 18f-synvest-1 is associated with amyloid β and tau PET deposition in humans.

    “we find a strong inverse association between [ 18 F]-SynVesT-1 PET uptake and amyloid beta and tau PET deposition”

    Humansbrain

    Imaging synaptic density in ageing and Alzheimer’s Disease with [ 18 F]-SynVesT-1

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

More on Amyloid β and tau PET deposition

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Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 1Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 01 paper in 12 months