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16α-hydroxyestradiol

Intervention

1 paper1 finding

PubChem 3269ChEBI 125457

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Institute on Aging and 2 more
  • Animals1

Mouse lifespan

NIA ITP

Outcomes

1

Inferred cause of death

no changein mice1

1 study

  1. 16α-hydroxyestradiol has no effect on inferred cause of death in mice.

    “There were no significant drug-induced alterations in inferred cause of death, although statistical power was low for such comparisons.”

    AnimalsUM-HET3 mice; statistical power was low

    End-of-life pathology in UM-HET3 mice treated with 16 α‑hydroxyestradiol or late‑start canagliflozin

    GeroScience2 Jul 2025

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