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V-FBR-FOS

Gene

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Cells1

Effects

2

Cell-cycle arrest

no changein rat cells1

1 study

  1. V-FBR-FOS has no effect on cell-cycle arrest in rat cells.

    “Whereas a wild-type SV40 large T antigen rescued tsa14 from a temperature-dependent growth arrest, v-FBR-fos failed to do so.”

    Cellstemperature-dependent growth arrest in tsa14 cells

    v-FBR-fos oncogene fails to rescue mammalian cells from growth arrest but affects the responses of human fibroblasts to heparin

    Anticancer researchJan 1, 2001

Lifespan

no changein human cells1

1 study

  1. V-FBR-FOS has no effect on lifespan in human cells.

    “Constitutive overexpression of v-FBR-fos in normal human fibroblasts (MRC-5) and of v-FBR-fos in human chondrocytes (HAC21) failed to immortalise them, extend their in vitro lifespan”

    Cellsconstitutive overexpressionfibroblast

    v-FBR-fos oncogene fails to rescue mammalian cells from growth arrest but affects the responses of human fibroblasts to heparin

    Anticancer researchJan 1, 2001

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