unc13

unc13 increases ethanol sensitivity in flies.

“Thr1729Met substitution within the C1 domain resulted in increased ethanol sensitivity.”

Model organismsThr1729Met substitution within C1 domain

Single nucleotide variants in UNC13C associated with neurodevelopmental disorders affect ethanol sensitivity in Drosophila

Biochemistry and biophysics reports·28 Nov 2025

unc13 decreases ethanol sensitivity in flies.

“two variants located outside the gene regions encoding known UNC13C domains caused a decreased ethanol sensitivity in Drosophila”

Model organismstwo variants outside known domains

Single nucleotide variants in UNC13C associated with neurodevelopmental disorders affect ethanol sensitivity in Drosophila

Biochemistry and biophysics reports·28 Nov 2025

unc13 has no effect on negative geotaxis in flies.

“However, none of the introduced mutations influenced Mendelian ratios, negative geotaxis, or lifespan of the fruit flies.”

Model organismssix patient-derived missense mutations introduced via CRISPR/Cas9

Single nucleotide variants in UNC13C associated with neurodevelopmental disorders affect ethanol sensitivity in Drosophila

Biochemistry and biophysics reports·28 Nov 2025

unc13 has no effect on lifespan in flies.

“However, none of the introduced mutations influenced Mendelian ratios, negative geotaxis, or lifespan of the fruit flies.”

Model organismssix patient-derived missense mutations introduced via CRISPR/Cas9

Single nucleotide variants in UNC13C associated with neurodevelopmental disorders affect ethanol sensitivity in Drosophila

Biochemistry and biophysics reports·28 Nov 2025