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unc-85

Gene

1 paper3 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Academy of Finland and 5 more
  • Model organisms1

Effects

2

Lifespan

is required forin worms1downin worms1

1 study

  1. unc-85 is required for lifespan in worms.

    “UNC-85 is required for epigenome-mediated longevity, as knockdown of the histone H3 lysine K4 methyltransferase ash-2 does not extend the lifespan of unc-85 mutants”

    Model organismsknockdown of ash-2

    Loss of the histone chaperone UNC-85/ASF1 inhibits the epigenome-mediated longevity and modulates the activity of one-carbon metabolism

    Cell stress & chaperonesApr 10, 2024

  2. unc-85 shortens lifespan in worms.

    “loss of UNC-85, the homolog of ASF1, leads to a shortened lifespan in a multicellular organism”

    Model organismsin unc-85 mutants

    Loss of the histone chaperone UNC-85/ASF1 inhibits the epigenome-mediated longevity and modulates the activity of one-carbon metabolism

    Cell stress & chaperonesApr 10, 2024

Methionine and one-carbon metabolism

upin worms1

1 study

  1. unc-85 increases methionine and one-carbon metabolism in worms.

    “loss of UNC-85 increases the activity of one-carbon metabolism”

    Model organismsloss of UNC-85

    Loss of the histone chaperone UNC-85/ASF1 inhibits the epigenome-mediated longevity and modulates the activity of one-carbon metabolism

    Cell stress & chaperonesApr 10, 2024

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