There are 5 papers on SALL1 in aging research: 1 observational study in people, 4 in animals.
1 new paper in 30 daysSee all 5
“is significantly down-regulated in the basal like breast cancer”
None of its findings points the other way.
- 1 lab in 1 country
- Funders: American Cancer Society and 3 more
- Humans1
- Animals3
- Model organisms1
Effects
3Cellular senescence
upin human cells1
1 study
Cellular senescence
upin human cells1
SALL1 increases cellular senescence in human cells (via recruitment of the NuRD complex).
“tumor suppression was mediated by recruitment of the Nucleosome Remodeling and Deacetylase (NuRD) complex by SALL1, which promoted cancer cell senescence.”
Cellsvia recruitment of the NuRD complex
Molecular cancer
Metastasis
downin mice1
1 study
Metastasis
downin mice1
SALL1 decreases metastasis in mice (SALL1 expression in murine breast cancer cells).
“SALL1 expression in human and murine breast cancer cells inhibited cancer cell growth and proliferation, metastasis, and promoted cell cycle arrest.”
AnimalsSALL1 expression in murine breast cancer cells
Molecular cancer
Breast cancer cell growth and proliferation
downin human cells1
1 study
Breast cancer cell growth and proliferation
downin human cells1
SALL1 decreases breast cancer cell growth and proliferation in human cells (SALL1 expression in breast cancer cells).
“SALL1 expression in human and murine breast cancer cells inhibited cancer cell growth and proliferation, metastasis, and promoted cell cycle arrest.”
CellsSALL1 expression in breast cancer cells
Molecular cancer
Associations
1Basal-like breast cancer
downin humans1
1 study
Basal-like breast cancer
downin humans1
SALL1 is associated with basal-like breast cancer in breast cancer patients.
“is significantly down-regulated in the basal like breast cancer”
Humansin breast cancer patientsbreast cancer tissue
Molecular cancer