RGS10

1. RGS10 is required for glucose tolerance in mice.

   “in Nlrp3 -/-/ Rgs10 -/- (dKO) males, the improvements in glucose tolerance, adipose remodeling, and hypothalamic microgliosis were abolished.”

   Animalsin Nlrp3-/- mice on high-fat dietmales

   RGS10 controls the metabolic and neuroinflammatory benefits of NLRP3 suppression in diet-induced obesity in male mice · Research Square · 2 Sep 2026 · Preprint

1. RGS10 inhibits NLRP3 inflammasome in cells.

   “In macrophages, loss of RGS10 enhanced calcium-dependent NLRP3 inflammasome activity during both priming and activation.”

   Cellsin macrophagesmacrophage

   RGS10 controls the metabolic and neuroinflammatory benefits of NLRP3 suppression in diet-induced obesity in male mice · Research Square · 2 Sep 2026 · Preprint

NLRP3 inflammasome →

1. Parkinson's disease is associated with RGS10 in humans.

   “RGS10 declined in aged and Parkinson’s disease human microglia”

   Humansaged and Parkinson's diseasemicroglia

   RGS10 controls the metabolic and neuroinflammatory benefits of NLRP3 suppression in diet-induced obesity in male mice · Research Square · 2 Sep 2026 · Preprint

Parkinson's disease →