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RFNG

Gene

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Chiba University and 3 more
  • Cells1

Effects

1

Notch signalling

downin human cells1

1 study

  1. RFNG inhibits notch signalling in human cells.

    “RFNG exhibited a greater inhibitory effect on JAG1-mediated activity of NOTCH3 R141C and C185R compared to that of NOTCH3 WT and R90C.”

    CellsJAG1-mediated

    The N-acetylglucosaminyltransferase Radical fringe contributes to defects in JAG1-dependent turnover and signaling of NOTCH3 CADASIL mutants

    The Journal of biological chemistrySep 19, 2024

More on Notch signalling

Upstream

1

Cellular senescence

upin human cells1

1 study

  1. Cellular senescence increases RFNG in human cells.

    “we found elevated NOTCH3 and Radical fringe (RFNG) expression in senescent human pericyte cells.”

    Cellsin senescent cellspericyte

    The N-acetylglucosaminyltransferase Radical fringe contributes to defects in JAG1-dependent turnover and signaling of NOTCH3 CADASIL mutants

    The Journal of biological chemistrySep 19, 2024

More on Cellular senescence

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