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PWP1

There is 1 paper on PWP1 in aging research: none in people yet, 1 in animals. The newest story, Nov 4, 2026: “Nutrient-sensing circuit guides gut cell development in flies”.

Gene

1 paper studies it2 findings

NCBI GeneTaxon

1 new paper in 30 daysSee all 1 papers on PWP1

At a glance

The findings reach worms or flies, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

Worms or flies: a single group. Cells, mice and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: European Union and 1 more
  • Model organisms1

Effects

2

Hedgehog signaling

upin flies1

1 study

  1. PWP1 activates hedgehog signaling in flies (high mTORC1 activity).

    “PWP1 controls gene expression to promote Hedgehog (Hh) signaling”

    Model organismshigh mTORC1 activitymidgut progenitor cell

    Nutrient-sensing circuit guides gut cell development in flies

    bioRxivPreprint

More on Hedgehog signaling

intestinal stem cell progeny differentiation toward the absorptive lineage

upin flies1

1 study

  1. PWP1 induces intestinal stem cell progeny differentiation toward the absorptive lineage in flies (fed animals).

    “PWP1 is necessary and sufficient for differentiation of intestinal stem cell progeny toward the absorptive lineage in fed animals.”

    Model organismsfed animalsmidgut

    Nutrient-sensing circuit guides gut cell development in flies

    bioRxivPreprint

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 11 paper in 12 months
bioRxiv

Nutrient-sensing circuit guides gut cell development in flies

Fruit fly experiments identified signals that controlled the development of nutrient-absorbing gut cells; disrupting the circuit impaired renewal during aging and…Fruit fly experiments identified signals that controlled the development of nutrient-absorbing gut cells; disrupting the circuit impaired renewal during aging and shortened lifespan.

Preprint: fly studyNutrient sensing
Paper

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