AgingResearch.NewsJoin free

PLCL1

Gene

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Fukuoka Dental College and 5 more
  • Animals1

Effects

4

Competitive reconstitution

upin animals1

1 study

  1. PLCL1 improves competitive reconstitution.

    “myeloid-skewed differentiation with impaired competitive reconstitution.”

    AnimalsShown by Plcl1 deficiencyhematopoietic stem cell

    Plcl1 Regulates Hematopoietic Stem Cell Function During Aging and Stress by Modulating Calcium Dynamics

    bioRxiv (Cold Spring Harbor Laboratory)16 Sep 2025Preprint

Non-canonical megakaryocyte progenitor expansion

downin animals1

1 study

  1. PLCL1 decreases non-canonical megakaryocyte progenitor expansion.

    “Plcl1 loss accelerated and amplified platelet rebound and the expansion of non-canonical megakaryocyte progenitors (ncMkPs)”

    AnimalsAcute hematopoietic stress; shown by Plcl1 lossnon-canonical megakaryocyte progenitor

    Plcl1 Regulates Hematopoietic Stem Cell Function During Aging and Stress by Modulating Calcium Dynamics

    bioRxiv (Cold Spring Harbor Laboratory)16 Sep 2025Preprint

Platelet rebound

downin animals1

1 study

  1. PLCL1 decreases platelet rebound.

    “Under acute hematopoietic stress, Plcl1 loss accelerated and amplified platelet rebound”

    AnimalsAcute hematopoietic stress; shown by Plcl1 loss

    Plcl1 Regulates Hematopoietic Stem Cell Function During Aging and Stress by Modulating Calcium Dynamics

    bioRxiv (Cold Spring Harbor Laboratory)16 Sep 2025Preprint

Basal intracellular calcium

upin animals1

1 study

  1. PLCL1 increases basal intracellular calcium.

    “Loss-of-function studies revealed that Plcl1 deficiency at steady state reduced basal intracellular calcium levels”

    AnimalsSteady state; shown by loss-of-function studieshematopoietic stem cell

    Plcl1 Regulates Hematopoietic Stem Cell Function During Aging and Stress by Modulating Calcium Dynamics

    bioRxiv (Cold Spring Harbor Laboratory)16 Sep 2025Preprint

More on Basal intracellular calcium

Latest

Related