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Animals1

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Science·28 Apr

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

Experiments in miceInterventions

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Cellular senescence1
DMD1
Mitochondrial unfolded protein response1
Mitochondrion1
NAD+ metabolism1
NAD+ precursors1
Stem cell maintenance1
Muscular dystrophy1
Nicotinamide riboside1

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Trials

AKG and Brain Health in AgingPhase 2Registered 6 Oct 2026, University of Oklahoma Safety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital)Phase 1Registered 2 Oct 2026, Vinmec Research Institute of Stem Cell and Gene Technology AI-Based Conversational Social Support for Older Adults With Heart FailureRegistered 7 Oct 2026, Chang Gung University of Science and Technology

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