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Mfs2

There is 1 paper on Mfs2 in aging research: none in people yet, 1 in animals.

Gene

1 paper studies it3 findings

NCBI GeneTaxon

See all 1 papers on Mfs2

At a glance

The findings reach worms or flies, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

Worms or flies: a single group. Cells, mice and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Harvard Catalyst and 8 more
  • Model organisms1

Interventions

1

High-phosphate diet

upin flies1

1 study

  1. High-phosphate diet induces Mfs2 in flies.

    “dietary Pi induces MFS2 expression”

    Model organisms

    Endocrine regulation of MFS2 by branchless controls phosphate excretion and stone formation in Drosophila renal tubules

    Scientific reports

More on High-phosphate diet

Effects

2

Lifespan

downin flies1

1 study

  1. Mfs2 shortens lifespan in flies (shown by genetic ablation).

    “genetic ablation of MFS2 increased fly life span”

    Model organismsshown by genetic ablation

    Endocrine regulation of MFS2 by branchless controls phosphate excretion and stone formation in Drosophila renal tubules

    Scientific reports

Stone formation

upin flies1

1 study

  1. Mfs2 increases stone formation in flies (shown by RNAi knockdown on high Pi medium).

    “RNAi-mediated knockdown of MFS2 increases blood (hemolymph) Pi and decreases formation of Malpighian tubule stones in flies cultured on high Pi medium.”

    Model organismsshown by RNAi knockdown on high Pi mediumMalpighian tubule

    Endocrine regulation of MFS2 by branchless controls phosphate excretion and stone formation in Drosophila renal tubules

    Scientific reports

More on Stone formation

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