AgingResearch.NewsJoin free

LPGAT1

Gene

2 papers3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 3 more
  • Humans1
  • Animals1

Effects

3

Lipid and ceramide metabolism

downin mouse cells1

1 study

  1. LPGAT1 decreases lipid and ceramide metabolism in mouse cells.

    “total lipid synthesis was reduced in isolated hepatocytes of LPGAT1 knockout mice.”

    Cellsgenetic ablationhepatocytes

    LPGAT1 controls the stearate/palmitate ratio of phosphatidylethanolamine and phosphatidylcholine in sn-1 specific remodeling

    The Journal of biological chemistryFeb 4, 2022

More on Lipid and ceramide metabolism

Body fat

downin mice1

1 study

  1. LPGAT1 decreases body fat in mice.

    “Lysophosphatidylglycerol acyltransferase 1 KO mice were leaner and had a shorter life span than their littermate controls.”

    Animalsgenetic ablation

    LPGAT1 controls the stearate/palmitate ratio of phosphatidylethanolamine and phosphatidylcholine in sn-1 specific remodeling

    The Journal of biological chemistryFeb 4, 2022

Lifespan

downin mice1

1 study

  1. LPGAT1 shortens lifespan in mice.

    “Lysophosphatidylglycerol acyltransferase 1 KO mice were leaner and had a shorter life span than their littermate controls.”

    Animalsgenetic ablation

    LPGAT1 controls the stearate/palmitate ratio of phosphatidylethanolamine and phosphatidylcholine in sn-1 specific remodeling

    The Journal of biological chemistryFeb 4, 2022

Latest

Related