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LAMININ

There are 2 papers on LAMININ in aging research: none in people yet, 2 in animals.

Gene

2 papers study it5 findings

See all 2

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: American Heart Association
  • Animals2

Effects

5

Transcytosis

downin mice1

1 study

  1. LAMININ decreases transcytosis in mice (shown by pericytic conditional knockout (PKO mice)).

    “abnormal paracellular transport, enhanced transcytosis”

    Animalsshown by pericytic conditional knockout (PKO mice)blood-brain barrier

    Pericytic Laminin Maintains Blood-Brain Barrier Integrity in an Age-Dependent Manner

    Translational stroke research

Pericyte coverage

upin mice1

1 study

  1. LAMININ increases pericyte coverage in mice (shown by pericytic conditional knockout (PKO mice)).

    “enhanced transcytosis, decreased pericyte coverage, and diminished AQP4 level are responsible for BBB disruption in PKO mice”

    Animalsshown by pericytic conditional knockout (PKO mice)brain

    Pericytic Laminin Maintains Blood-Brain Barrier Integrity in an Age-Dependent Manner

    Translational stroke research

More on Pericyte coverage

AQP4

upin mice1

1 study

  1. LAMININ increases AQP4 in mice (shown by pericytic conditional knockout (PKO mice)).

    “diminished AQP4 level are responsible for BBB disruption in PKO mice”

    Animalsshown by pericytic conditional knockout (PKO mice)brain

    Pericytic Laminin Maintains Blood-Brain Barrier Integrity in an Age-Dependent Manner

    Translational stroke research

More on AQP4

Lifespan

no changein mice1

1 study

  1. LAMININ showed no clear effect on lifespan in mice (pericytic laminin conditional knockout on C57Bl6 dominant background).

    “in C57Bl6 dominant background, the PKO mice fail to show hydrocephalus, have a normal lifespan”

    Animalspericytic laminin conditional knockout on C57Bl6 dominant background

    Pericytic Laminin Maintains Blood-Brain Barrier Integrity in an Age-Dependent Manner

    Translational stroke research

Blood-brain barrier integrity

is required forin mice1

1 study

  1. LAMININ is required for blood-brain barrier integrity in mice (shown by pericytic conditional knockout; age-dependent).

    “pericyte-derived laminin plays an indispensable and age-dependent role in the maintenance of BBB integrity under homeostatic conditions”

    Animalsshown by pericytic conditional knockout; age-dependentblood-brain barrier

    Pericytic Laminin Maintains Blood-Brain Barrier Integrity in an Age-Dependent Manner

    Translational stroke research

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