HSD3B

There are 7 papers on HSD3B in aging research: none in people yet, 6 in animals, 1 in cells.

7 papers study it1 finding

See all 7 papers on HSD3B

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

1 lab in 1 country

Funders: Government of Japan Ministry of Education Culture Sports Science and Technology and 3 more
1 of 1 finding with company ties

Animals6
Cells1

Effects

1

Meibomian gland atrophy

downin humans1

1 study

HSD3B prevents meibomian gland atrophy in humans (shown by genetic ablation).
“Genetic ablation of 3β-HSD nullified local steroidogenesis and led to atrophy of the meibomian gland.”
Animalsshown by genetic ablationmeibomian gland
Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction
Nature agingFeb 1, 2022

Latest

3 papers in 12 months

eLifeMar 25

NAD boosting mediated by CD38 inhibition drives reversal of a pathological vicious cycle of intracrine activity and inflammation in eyelid meibomian gland dysfunction

Preprint: experiments in miceInterventions

eLifeMar 25

NAD boosting mediated by CD38 inhibition drives reversal of a pathological vicious cycle of intracrine activity and inflammation in eyelid meibomian gland dysfunction

Preprint: experiments in miceInterventions

Poultry ScienceMar 16

Natural astaxanthin enhances testosterone synthesis by improving mitochondrial function and reducing oxidative stress in Leydig cells

Experiments in cellsAstaxanthin

Scientific ReportsFeb 22

Mechanistic insight into the protective effects of fisetin against arsenic-induced reproductive toxicity in male rats

Experiments in 48 ratsFisetin

Nature AgingFeb 1

Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction

Experiments in animalsNAD+

Advances in GerontologyJan 15

The decrease in the basal and luteinizing hormone receptor agonist-stimulated production of testosterone in aging male rats

Experiments in ratsMechanisms

Free Radical Biology & MedicineMay 21

Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice

Experiments in miceJNK signaling