HELB

1. HELB increases follicle depletion in mice.

   “aged Helb+/D112Y females showed decreased ovarian weight and accelerated follicle depletion.”

   Animalsheterozygous missense variant Helb+/D112Yovaryfemales

   Genetic variants in HELB contribute to premature ovarian insufficiency and early age of natural menopause

   JCI insight·10 Nov 2025

1. HELB decreases ovarian weight in mice.

   “Consistently, aged Helb+/D112Y females showed decreased ovarian weight and accelerated follicle depletion.”

   Animalsheterozygous missense variant Helb+/D112Yovaryfemales

   Genetic variants in HELB contribute to premature ovarian insufficiency and early age of natural menopause

   JCI insight·10 Nov 2025

1. HELB impairs reproductive lifespan in mice.

   “The Helb-mutated female mice exhibited reduced litter sizes and prolonged interlitter intervals compared with wild-type mice after reaching 10 months of age, leading to a shortened reproductive lifespan.”

   Animalsheterozygous missense variant Helb+/D112Yfemales

   Genetic variants in HELB contribute to premature ovarian insufficiency and early age of natural menopause

   JCI insight·10 Nov 2025

1. HELB is associated with premature ovarian insufficiency in humans.

   “identified a rare heterozygous missense variant in DNA helicase B (HELB) (c.349G>T, p.Asp117Tyr) in a Chinese family with POI and early menopause.”

   Humansheterozygous missense variant c.349G>T, p.Asp117Tyrfemales

   Genetic variants in HELB contribute to premature ovarian insufficiency and early age of natural menopause

   JCI insight·10 Nov 2025

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