AgingResearch.NewsJoin free

FLRT2

Gene

2 papers study it6 findings

HGNCNCBI GeneTaxon

See all 2

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 2 countries
  • Funders: Ministry of Science and ICT, South Korea and 3 more
  • Animals1
  • Cells1

Effects

5

Cellular senescence

downin human cells2

2 studies

  1. FLRT2 prevents cellular senescence in human cells.

    “FLRT2 in preventing endothelial cell senescence and vascular aging”

    Cellsin human endothelial cells

    FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway

    JCI insight

  2. FLRT2 inhibits cellular senescence in human cells.

    “FLRT2 silencing in human endothelial cells induced senescence through mTORC2, but not mTORC1, AKT, and p53.”

    Cellsshown by FLRT2 silencingendothelial cell

    FLRT2 plays a critical role in endothelial cell senescence and vascular aging

    Research SquarePreprint

More on Cellular senescence

Premature vascular aging phenotype

downin mice1

1 study

  1. FLRT2 decreases premature vascular aging phenotype in mice.

    “overexpression of FLRT2 rescued a premature vascular aging phenotype”

    Animalsvascular tissue

    FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway

    JCI insight

Vascular aging

downin mice1

1 study

  1. FLRT2 protects against vascular aging in mice.

    “FLRT2 silencing in mice promoted vascular aging”

    Animalsvascular tissue

    FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway

    JCI insight

Vascular aging phenotype

downin mice1

1 study

  1. FLRT2 decreases vascular aging phenotype in mice.

    “FLRT2 silencing in mice promoted vascular aging and overexpression of FLRT2 rescued a premature vascular aging phenotype.”

    Animalsshown by Flrt2 silencing and overexpressionvascular tissue

    FLRT2 plays a critical role in endothelial cell senescence and vascular aging

    Research SquarePreprint

ITGB4 phosphorylation

upin human cells1

1 study

  1. FLRT2 increases ITGB4 phosphorylation in human cells.

    “FLRT2 directly associated with ITGB4 and thereby promoted ITGB4 phosphorylation”

    Cellsendothelial cell

    FLRT2 plays a critical role in endothelial cell senescence and vascular aging

    Research SquarePreprint

More on ITGB4 phosphorylation

Latest

Related