ESPL1
- 1 lab in 1 country
- Funder: Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Animals1
Effects
1Chromosome cohesion
downin mice1
1 study
Chromosome cohesion
downin mice1
ESPL1 decreases chromosome cohesion in mice.
“To directly target cohesion, we increased the activity of separase, the protease that cleaves the meiotic cohesin REC8, in oocytes.”
Animalspremature activation in oocytesoocyte
Biology of reproduction24 Aug 2011
Upstream
1CDK1
downin mice1
1 study
CDK1
downin mice1
CDK1 inhibits ESPL1 in mice.
“cohesion is protected by two independent mechanisms that inhibit separase, securin and an inhibitory phosphorylation of separase by CDK1”
Animalsoocyte
Biology of reproduction24 Aug 2011
Latest
Biology of Reproduction
Age-dependent susceptibility of chromosome cohesion to premature separase activation in mouse oocytes
Experiments in animalsMechanisms