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ERO1B

Gene

2 papers study it2 findings

HGNCNCBI GeneTaxon

See all 2

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 3 countries
  • Funders: Biomedical Research Council and others
  • 2 of 2 findings with company ties
  • Humans1
  • In silico1

Upstream

1

β-cell glucose sensitivity

downin humans1

1 study

  1. β-cell glucose sensitivity decreases ERO1B in humans.

    “individuals with lower βGS exhibited reduced levels of insulin maturation (ERO1B) and antiapoptotic proteins (CASP8, PAK2, SKP1)”

    Humansin individuals with lower beta cell glucose sensitivitypancreatic islets

    Proteomic analyses of human islets reveal potential markers of β cell dysfunction during prediabetes

    JCI insight

Associations

1

Type 2 diabetes

upin humans1

1 study

  1. ERO1B is associated with type 2 diabetes in humans.

    “reveals biologically plausible mechanisms, including the association of T2D with an sQTL that creates a nonsense isoform in ERO1B”

    HumanssQTL creates a nonsense isoformpancreatic islets

    Genetic regulation of RNA splicing in human pancreatic islets

    Genome biology

More on Type 2 diabetes

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 1Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 01 paper in 12 months

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