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EPOR

Gene

5 papers study it3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: European Commission and 2 more
  • Animals4
  • Cells1

Effects

3

Iron deposition

upin mice1

1 study

  1. EPOR increases iron deposition in mice.

    “contributes to increased iron deposition in the aged mtHEPOR mice”

    Animalsin aged mtHEPOR mice

    Developmental changes in iron metabolism and erythropoiesis in mice with human gain-of-function erythropoietin receptor

    American journal of hematology

Lifespan

downin mice1

1 study

  1. EPOR shortens lifespan in mice.

    “mtHEPOR erythrocytes had a reduced lifespan”

    Animalsin mtHEPOR mice

    Developmental changes in iron metabolism and erythropoiesis in mice with human gain-of-function erythropoietin receptor

    American journal of hematology

Inflammatory stress

upin mice1

1 study

  1. EPOR increases inflammatory stress in mice.

    “myeloid expansion, and local bone marrow inflammatory stress”

    Animalsin mtHEPOR mice with agingbone marrow

    Developmental changes in iron metabolism and erythropoiesis in mice with human gain-of-function erythropoietin receptor

    American journal of hematology

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