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ENGRAILED-1

There is 1 paper on ENGRAILED-1 in aging research: none in people yet, 1 in animals.

Gene

1 paper studies it1 finding

See all 1 papers on ENGRAILED-1

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

Mice: a single group. Cells, worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Agence Nationale de la Recherche and 3 more
  • Animals1

Effects

1

Alpha-motoneuron survival

is required forin mice1

1 study

  1. ENGRAILED-1 is required for alpha-motoneuron survival in mice (extracellular ENGRAILED-1 neutralization by a secreted single-chain antibody).

    “Neutralizing extracellular ENGRAILED-1 by expressing a secreted single-chain antibody blocks its capture by spinal motoneurons resulting in α-motoneuron loss and limb weakness”

    Animalsextracellular ENGRAILED-1 neutralization by a secreted single-chain antibodyspinal cord

    ENGRAILED-1 transcription factor has a paracrine neurotrophic activity on adult spinal α-motoneurons

    EMBO reports

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