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endu-2

Gene

1 paper2 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Model organisms1

Effects

2

Longevity

mediatesin worms1

1 study

  1. endu-2 mediates longevity in worms.

    “the hormetic long-term effects of a transient HS are mediated by the RNA-binding protein ENDU-2 that determines aging and longevity.”

    Model organismshormetic effects of transient heat shock

    Reprogramming of transcriptome after hormetic heat stress by the endoribonuclease ENDU‑2 improves lifespan and stress resistance in C. elegans

    Research SquareDec 21, 2022Preprint

Post-heat-shock transcriptional reprogramming

is required forin worms1

1 study

  1. endu-2 is required for post-heat-shock transcriptional reprogramming in worms.

    “This transcriptional reprogramming depends on the function of the endoribonuclease ENDU-2 but not the heat shock factor 1 (HSF-1).”

    Model organismsfollowing transient heat shock

    Reprogramming of transcriptome after hormetic heat stress by the endoribonuclease ENDU‑2 improves lifespan and stress resistance in C. elegans

    Research SquareDec 21, 2022Preprint

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