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eif-3.L

There is 1 paper on eif-3.L in aging research: none in people yet, 1 in animals.

Gene

1 paper studies it1 finding

NCBI GeneTaxon

See all 1 papers on eif-3.L

At a glance

The findings reach worms or flies, none yet in people. 1 lab in 1 country.

Worms or flies: a single group. Cells, mice and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Howard Hughes Medical Institute and 2 more
  • Model organisms1

Effects

1

Resistance to ER stress

upin worms1

1 study

  1. eif-3.L increases resistance to ER stress in worms (Shown by mutation in eif-3.L; independent of IRE-1-XBP-1, ATF-6, PEK-1, and DAF-16).

    “Mutations in eif-3.K or eif-3.L also confer enhanced resistance to ER stress”

    Model organismsShown by mutation in eif-3.L; independent of IRE-1-XBP-1, ATF-6, PEK-1, and DAF-16

    Mutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in Caenorhabditis elegans

    PLoS genetics

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