Aging Cell
Protein loss reduced signs of senescence in mouse fat tissue
Experiments comparing male mice with and without a regulatory protein found altered fat composition and reduced senescence, a state in which cells stop dividing.Experiments comparing male mice with and without a regulatory protein found altered fat composition and reduced senescence, a state in which cells stop dividing.
Mouse studyCellular senescence
Who was studiedAged high-fat-fed male mice, ~4–6 months, against wild-type mice
What changedSigns of cellular senescence in fat tissue were lower in mice lacking MKP-2 than in wild-type mice
The catchKnockout mice ate less, so reduced caloric intake could explain their lower senescence markers
