BSX

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Animals1

Effects

Metabolic homeostasis

no changein mice1

1 study

BSX has no effect on metabolic homeostasis in mice.
“Bsx Q159K/Q159K mice maintain metabolic homeostasis, a lean body composition into advanced age, and a normal lifespan under ad libitum feeding and controlled LD.”
AnimalsBsx Q159K/Q159K mice under ad libitum feeding and controlled light-dark conditions
A human missense variant in BSX decouples circadian behaviour from metabolic rhythmicity while preserving lifespan in mice
bioRxiv (Cold Spring Harbor Laboratory)9 Dec 2025Preprint

Lifespan

no changein mice1

1 study

BSX has no effect on lifespan in mice.
“Bsx Q159K/Q159K mice maintain metabolic homeostasis, a lean body composition into advanced age, and a normal lifespan under ad libitum feeding and controlled LD.”
AnimalsBsx Q159K/Q159K mice under ad libitum feeding and controlled light-dark conditions
A human missense variant in BSX decouples circadian behaviour from metabolic rhythmicity while preserving lifespan in mice
bioRxiv (Cold Spring Harbor Laboratory)9 Dec 2025Preprint

Food anticipatory activity

downin mice1

1 study

BSX decreases food anticipatory activity in mice.
“Bsx Q159K/Q159K mice lack FAA during restricted feeding and fail to increase locomotor activity upon food deprivation.”
AnimalsBsx Q159K/Q159K mice during restricted feeding
A human missense variant in BSX decouples circadian behaviour from metabolic rhythmicity while preserving lifespan in mice
bioRxiv (Cold Spring Harbor Laboratory)9 Dec 2025Preprint

Circadian behavioural rhythms

downin mice1

1 study

BSX decreases circadian behavioural rhythms in mice.
“BSX causes profound loss of circadian behavioural rhythms and food anticipatory activity (FAA) in mice.”
AnimalsQ159K missense variant
A human missense variant in BSX decouples circadian behaviour from metabolic rhythmicity while preserving lifespan in mice
bioRxiv (Cold Spring Harbor Laboratory)9 Dec 2025Preprint

Associations

Respiratory exchange ratio rhythmicity

mixedin mice1

1 study

BSX is associated with respiratory exchange ratio rhythmicity in mice.
“a rhythmic respiratory exchange ratio (RER) pattern that differs substantially from that of wild-type mice and is markedly attenuated under LD conditions.”
AnimalsBsx Q159K/Q159K mice under constant darkness or light-dark conditions
A human missense variant in BSX decouples circadian behaviour from metabolic rhythmicity while preserving lifespan in mice
bioRxiv (Cold Spring Harbor Laboratory)9 Dec 2025Preprint

Latest

1 in 12 months

bioRxiv9 Dec

A human missense variant in BSX decouples circadian behaviour from metabolic rhythmicity while preserving lifespan in mice

Preprint: experiments in miceMechanisms

Paper

BSX

Effects

Associations

Latest

A human missense variant in BSX decouples circadian behaviour from metabolic rhythmicity while preserving lifespan in mice

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