Atpalpha

Gene

1 paper4 findings

Taxon

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Model organisms1

Effects

4

Neuronal morphology defect

downin flies1

1 study
  1. Atpalpha impairs neuronal morphology defect in flies.

    “Flies heterozygous for AtpαTTTF mutations have motor performance defects, a reduced lifespan, seizures, and an abnormal neuronal morphology.”

    Model organismsheterozygous AtpαTTTF mutations

    Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

    Neural regeneration researchDec 21, 2023

Refractory seizures

upin flies1

1 study
  1. Atpalpha induces refractory seizures in flies.

    “Flies heterozygous for AtpαTTTF mutations have motor performance defects, a reduced lifespan, seizures, and an abnormal neuronal morphology.”

    Model organismsheterozygous AtpαTTTF mutations

    Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

    Neural regeneration researchDec 21, 2023

More on Refractory seizures

Motor performance

downin flies1

1 study
  1. Atpalpha impairs motor performance in flies.

    “Flies heterozygous for AtpαTTTF mutations have motor performance defects, a reduced lifespan, seizures, and an abnormal neuronal morphology.”

    Model organismsheterozygous AtpαTTTF mutations

    Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

    Neural regeneration researchDec 21, 2023

Lifespan

downin flies1

1 study
  1. Atpalpha shortens lifespan in flies.

    “Flies heterozygous for AtpαTTTF mutations have motor performance defects, a reduced lifespan, seizures, and an abnormal neuronal morphology.”

    Model organismsheterozygous AtpαTTTF mutations

    Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

    Neural regeneration researchDec 21, 2023

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