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arip-4

Gene

1 paper studies it2 findings

Taxon

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Institute of General Medical Sciences and 1 more
  • Model organisms1

Effects

2

Healthspan

downin worms1

1 study

  1. arip-4 impairs healthspan in worms.

    “A null mutation in arip-4 extends the life span and health span of both wild type and a mitochondrial mutant”

    Model organismsshown by arip-4 null mutation in wild type and a mitochondrial mutant

    The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways

    Proceedings of the National Academy of Sciences of the United States of America

EOL-1 transcription

upin worms1

1 study

  1. arip-4 activates EOL-1 transcription in worms.

    “NHR-45/ARIP-4 also regulates the transcriptional activation of the eol-1 gene”

    Model organismsmitochondrial dysfunction

    The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways

    Proceedings of the National Academy of Sciences of the United States of America

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