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AP1B1

Gene

1 paper studies it1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Institute on Aging and 1 more
  • Humans1

Effects

1

Progressive parkinsonism

downin humans1

1 study

  1. AP1B1 decreases progressive parkinsonism in humans (Estimate -0.504, SE 0.121, p = 3.12 × 10-5).

    “A higher level of AP1B1 (Estimate -0.504, SE 0.121, p = 3.12 × 10-5) and GNG3 (Estimate -0.276, SE 0.068, p = 4.82 × 10-5) was associated with slower progressive parkinsonism.”

    Humansafter controlling for age, sex, and 10 brain pathologiesdorsal lateral prefrontal cortexn = 391

    Proteome-Wide Discovery of Cortical Proteins That May Provide Motor Resilience to Offset the Negative Effects of Pathologies in Older Adults

    The journals of gerontology. Series A, Biological sciences and medical sciences

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