Vertebral fragility fracture

Disease

4 papers study it22 more mention it4 findings

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  • Human trial1
  • Humans3

Associations

4

Severe sarcopenia

upin humans1OR 4.04

1 study
  1. Severe sarcopenia raises the risk of vertebral fragility fracture in humans (OR 4.04 (95% CI: 1.24-13.20), p for trend = 0.014).

    “severe sarcopenia had a dose-dependent association with prevalence of thoracic vertebral fragility fractures with ORs of 2.56 (95% CI: 0.66-9.91) and 4.04 (95% CI: 1.24-13.20), respectively; p for trend = 0.014”

    Humansdose-dependent association by severity of sarcopenia; p for trend = 0.014n = 300

    Dose-Dependent Association between Sarcopenia and Moderate-To-Severe Thoracic Vertebral Fragility Fracture in Older Adults

    Gerontology

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Sarcopenia

upin humans1OR 3.29

1 study
  1. Sarcopenia raises the risk of vertebral fragility fracture in humans (OR 3.29, 95% CI: 1.23-8.78, p = 0.018).

    “sarcopenia plus severe sarcopenia was identified as a risk factor for moderate-to-severe thoracic vertebral fragility fracture (odds ratio [OR] = 3.29, 95% CI: 1.23-8.78, p = 0.018)”

    Humansadjusted for confounding factors; in older adults with increased fracture riskn = 300

    Dose-Dependent Association between Sarcopenia and Moderate-To-Severe Thoracic Vertebral Fragility Fracture in Older Adults

    Gerontology

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Hip abductor muscle strength

downin humans1

1 study
  1. Vertebral fragility fracture is associated with hip abductor muscle strength in humans (p = 0.001).

    “VFF was only associated with low peak hip abductor torque (p = 0.001) after adjustments.”

    Humansolder women with low bone massfemalesn = 94

    Association between vertebral fragility fractures, muscle strength and physical performance: A cross-sectional study

    Annals of physical and rehabilitation medicine

Osteoporosis treatment

upin humans1

1 study
  1. Osteoporosis treatment is associated with vertebral fragility fracture in humans (9.9% vs 5.3%).

    “9.9% of the treated patients developed new vertebral fragility fractures, compared with 5.3% of the untreated patients.”

    Humanspostmenopausal womenbone2.5 yearsfemales

    Comparison between real-world practice and application of the FRAX algorithm in the treatment of osteoporosis

    Aging clinical and experimental research

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