Uveal melanoma

2 papers6 findings

Human studies associate uveal melanoma risk with reduced tanning ability, freckling propensity and lighter eye colour, and link it to a family history of cutaneous melanoma. A human retinal study reports greater mean vessel length and lower microvascular density in uveal melanoma than in naevi.

Humans2

Effects

Mean vessel length

upin humans1

1 study

Uveal melanoma increases mean vessel length in humans (B = 5.54, p = 0.009).
Humanscompared to nevusretina
Physical Activity Is Associated with Higher Retinal Microvascular Density in Uveal Melanoma and Nevus
Cancers4 Aug 2026

Associations

Family history of cutaneous melanoma

upin humans1

1 study

Family history of cutaneous melanoma is associated with uveal melanoma in humans.
Humans
Phenotypic and genotypic risk factors for uveal melanoma in a high ambient UV radiation environment
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology11 Sep 2026

Reduced tanning ability

upin humans1

1 study

Reduced tanning ability raises the risk of uveal melanoma in humans.
Humans
Phenotypic and genotypic risk factors for uveal melanoma in a high ambient UV radiation environment
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology11 Sep 2026

Freckling propensity

upin humans1

1 study

Freckling propensity raises the risk of uveal melanoma in humans.
Humans
Phenotypic and genotypic risk factors for uveal melanoma in a high ambient UV radiation environment
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology11 Sep 2026

Lighter eye color

upin humans1

1 study

Lighter eye color raises the risk of uveal melanoma in humans.
Humans
Phenotypic and genotypic risk factors for uveal melanoma in a high ambient UV radiation environment
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology11 Sep 2026