Unruptured intracranial aneurysm

1. Hypertension raises the risk of unruptured intracranial aneurysm in humans (adjusted OR 1.65, 95% CI 1.22-2.12).

   Humansn = 4,711

   Prevalence and risk factors of unruptured intracranial aneurysms in Chinese adults · World neurosurgery · 25 Sep 2026

2. Hypertension raises the risk of unruptured intracranial aneurysm in humans (RR 1.6 (1.5-1.7)).

   Reviewn = 83,053

   Prevalence of unruptured intracranial aneurysms according to comorbidities, risk factors, country, and time period: a systematic review and meta-analysis · The Lancet. Neurology · 1 Sep 2026

Hypertension →

1. FASH-D model predicts unruptured intracranial aneurysm in humans (AUC 0.86, 95% CI 0.84-0.89).

   Humansn = 4,711

   Prevalence and risk factors of unruptured intracranial aneurysms in Chinese adults · World neurosurgery · 25 Sep 2026

1. Diabetes mellitus raises the risk of unruptured intracranial aneurysm in humans (adjusted OR 1.63, 95% CI 1.33-2.00).

   Humansn = 4,711

   Prevalence and risk factors of unruptured intracranial aneurysms in Chinese adults · World neurosurgery · 25 Sep 2026

Diabetes mellitus →

1. Female sex raises the risk of unruptured intracranial aneurysm in humans (adjusted OR 1.33, 95% CI 1.08-1.63).

   Humansfemalesn = 4,711

   Prevalence and risk factors of unruptured intracranial aneurysms in Chinese adults · World neurosurgery · 25 Sep 2026

1. Older age raises the risk of unruptured intracranial aneurysm in humans (adjusted OR 1.03, 95% CI 1.02-1.04).

   Humansn = 4,711

   Prevalence and risk factors of unruptured intracranial aneurysms in Chinese adults · World neurosurgery · 25 Sep 2026

1. Autosomal dominant polycystic kidney disease is associated with unruptured intracranial aneurysm in humans (PR 4.4 (1.5-12.6)).

   Reviewn = 1,990

   Prevalence of unruptured intracranial aneurysms according to comorbidities, risk factors, country, and time period: a systematic review and meta-analysis · The Lancet. Neurology · 1 Sep 2026

Autosomal dominant polycystic kidney disease →

1. Connective-tissue disorder is associated with unruptured intracranial aneurysm in humans (PR 3.9 (2.0-7.6)).

   Reviewn = 879

   Prevalence of unruptured intracranial aneurysms according to comorbidities, risk factors, country, and time period: a systematic review and meta-analysis · The Lancet. Neurology · 1 Sep 2026

Connective-tissue disorder →

1. Smoking raises the risk of unruptured intracranial aneurysm in humans (RR 1.4 (1.2-1.6)).

   Reviewn = 27,911

   Prevalence of unruptured intracranial aneurysms according to comorbidities, risk factors, country, and time period: a systematic review and meta-analysis · The Lancet. Neurology · 1 Sep 2026

Smoking →