Type II GM1 gangliosidosis

1. Type II GM1 gangliosidosis is associated with Brain Structures Age Gap Estimation in humans (average BSAGE = 35.50 years in late-infantile, 21.19 years in juvenile, 0.03 years in NC).

   “Cross-sectional evaluations of BSAGE for the whole brain show an average BSAGE = 35.50 years in the late-infantile cohort, 21.19 years in the juvenile cohort, and 0.03 years in NC.”

   Humanscross-sectional evaluationsbrainn = 41

   Brain aging in Type II GM1 gangliosidosis

   Communications medicine·6 Jul 2026

More on Brain Structures Age Gap Estimation

1. Type II GM1 gangliosidosis is associated with predicted brain age in humans (12.25 per chronological year).

   “NC shows whole-brain aging at a rate of 0.83 per chronological year compared with 1.57 in juvenile GM1 patients and 12.25 in late-infantile GM1 patients.”

   Humanslate-infantile GM1 patientsbrainn = 15

   Brain aging in Type II GM1 gangliosidosis

   Communications medicine·6 Jul 2026

More on Predicted brain age