The American Journal of Pathology
Human gene variant linked to chronic inflammation in older mice
An experiment in 14- to 16-month-old mice linked a human gene variant to weaker repair-related responses two weeks after chemotherapy.An experiment in 14- to 16-month-old mice linked a human gene variant to weaker repair-related responses two weeks after chemotherapy.
Mouse studyInflammation
Who was studiedOlder mice carrying human APOE variants, 2 weeks, against APOE3 mice
What changedAPOE4 mice had higher blood levels of inflammatory signals than APOE3 mice before chemotherapy
The catchFollow-up lasted only 2 weeks, limiting assessment of long-term inflammation