Nonvertebral fracture

1. Cholecalciferol has no effect on nonvertebral fracture in humans (HR 0.97 (95% CI 0.87–1.07, P = 0.50)).

   “nonvertebral fractures (hazard ratio, 0.97; 95% CI, 0.87 to 1.07; P = 0.50)”

   Human trial2000 IU per daymedian follow-up of 5.3 yearsn = 25,871

   Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults

   The New England journal of medicine·28 Jul 2022

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1. Uric acid lowers the risk of nonvertebral fracture in humans (OR = 0.51, 95% CI 0.29-0.89, p = .018).

   “and nonvertebral (OR = 0.51, 95% CI 0.29-0.89, p = .018) fractures”

   Humansmales

   Serum uric acid is associated with bone health in older men: a cross-sectional population-based study

   Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·1 May 2011

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1. Alfacalcidol lowers the risk of nonvertebral fracture in humans (8 patients with fractures on placebo versus 1 on treatment; reported odds ratio 9.8).

   “Eight patients sustained fractures (six at the hip and two at other sites) in the placebo group, and one hip fracture occurred among treated patients”

   Human trialParkinson's disease; compared with placebo1 microg daily18 monthsn = 86

   Amelioration of osteopenia and hypovitaminosis D by 1alpha-hydroxyvitamin D3 in elderly patients with Parkinson's disease

   Journal of neurology, neurosurgery, and psychiatry·1 Jan 1999

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1. Nonvertebral fracture is associated with postload insulin in humans (12.5 mU/L lower insulin; p < 0.001).

   “Subjects with a history of nonvertebral fractures had a lower BMD and lower postload insulin levels than those without.”

   HumansHistory of nonvertebral fractures versus no such historymales

   Hyperinsulinemia and bone mineral density in an elderly population: The Rotterdam Study

   Bone·1 Jun 1996

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