Non-vertebral fracture

1. Obesity lowers the risk of non-vertebral fracture in humans (OR: 0.54; CI:0.31, 0.94).

   “Conversely, obese older adults by BMI had a significantly lower likelihood (OR: 0.54; CI:0.31, 0.94) of non-vertebral fractures”

   Humansdefined by BMIup to 10 yearsn = 1,099

   Incidence and predictors of fractures in older adults with and without obesity defined by body mass index versus body fat percentage

   Bone·27 Jul 2020

2. Obesity raises the risk of non-vertebral fracture in humans (OR: 1.88; CI:1.16, 3.04).

   “non-vertebral fractures (OR: 1.88; CI:1.16, 3.04) compared with non-obese after adjusting for confounders.”

   Humansdefined by body fat percentageup to 10 yearsn = 1,099

   Incidence and predictors of fractures in older adults with and without obesity defined by body mass index versus body fat percentage

   Bone·27 Jul 2020

More on Obesity

1. Cholecalciferol + calcium lowers the risk of non-vertebral fracture in humans (OR 0.80, 95% CI 0.72-0.89).

   “A meta-analysis of the seven RCTs to identify the incidence of non-vertebral fracture gave the OR of 0.80; 95% CI: 0.72, 0.89; p < .0001.”

   Review

   What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis

   International journal of older people nursing·17 Jul 2022

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1. Sarcopenic obesity raises the risk of non-vertebral fracture in humans (IRR 3.6, 95% CI 1.7-7.4).

   “Sarcopenic obese men had higher non-vertebral fracture rates compared to non-sarcopenic non-obese (incidence rate ratio: 3.0; 95 % CI 1.7-5.5), and obese alone (3.6; 1.7-7.4).”

   Humanscompared with obese alone10.7 ± 0.7 yearsmalesn = 563

   Associations of Sarcopenic Obesity and Dynapenic Obesity with Bone Mineral Density and Incident Fractures Over 5-10 Years in Community-Dwelling Older Adults

   Calcified tissue international·4 Mar 2016

More on Sarcopenic obesity