Cholecalciferol + calcium

1 paper2 findings

PubChem 5280795 PubChem 5460341 ChEBI 28940 ChEBI 22984

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Associations

Non-vertebral fracture

downin humans1OR 0.8

1 study

Cholecalciferol + calcium lowers the risk of non-vertebral fracture in humans (OR 0.80, 95% CI 0.72-0.89).
“A meta-analysis of the seven RCTs to identify the incidence of non-vertebral fracture gave the OR of 0.80; 95% CI: 0.72, 0.89; p < .0001.”
Review
What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis
International journal of older people nursing17 Jul 2022