New-onset stroke risk

1. Frailty index is associated with new-onset stroke risk in humans (Non-linear association; exploratory threshold FI = 0.18 (95% CI: 0.1–0.2)).

   “FI was significantly associated with new-onset stroke risk in a non-linear manner (likelihood ratio test p < 0.001)”

   HumansChinese adults with gastrointestinal or liver diseasesMean follow-up of 8 years55.78% femalesn = 3,682

   Association Between Frailty Index and New-Onset Stroke in Middle-Aged and Elderly Chinese Adults with Gastrointestinal or Liver Diseases: A Longitudinal Cohort Study

   Journal of clinical medicine·27 Sep 2026

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