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Metastatic colorectal cancer at diagnosis

Disease

1 paper1 finding

  • Humans1

Associations

1

Polygenic risk score

upin humans1

1 study

  1. Polygenic risk score is associated with metastatic colorectal cancer at diagnosis in humans.

    “The increase in PRS was associated with elevated risks of both metastatic CRC at diagnosis and CRC-specific mortality”

    HumansAverage-risk UK Biobank participantsn = 353,118

    Bowel cancer risk estimates suggest tailored screening ages

    International journal of cancer12 Oct 2026

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International Journal of Cancer

Bowel cancer risk estimates suggest tailored screening ages

Modelled ages ranged from before 40 for men with high genetic risk scores and family history to after 60 for women with low scores and no family history.Modelled ages ranged from before 40 for men with high genetic risk scores and family history to after 60 for women with low scores and no family history.

Cohort study of 353,118 peopleBiomarkers
Paper

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