Late-onset multiple sclerosis

1. Late-onset multiple sclerosis is associated with spinal cord lesions in humans (72% vs 55%, p=0.24).

   “Although spinal cord lesions were more frequent in patients with late-onset MS (72% vs 55%, p=0.24), the difference was not statistically significant.”

   Humanslate-onset multiple sclerosisn = 25

   Age-related aspects of multiple sclerosis

   Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·Jan 1, 2026

1. Late-onset multiple sclerosis is associated with walking distance < 120 m in humans (48% vs. 15%, p=0.02).

   “Patients with late-onset MS were also more likely to have a walking distance of less than 120 meters than the comparison group (48% vs. 15%, p=0.02).”

   Humanslate-onset multiple sclerosisn = 25

   Age-related aspects of multiple sclerosis

   Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·Jan 1, 2026

1. Late-onset multiple sclerosis is associated with motor disorders in humans (48% vs. 15%, p=0.02).

   “Motor disorders were significantly more common as initial symptoms in this group (48% vs. 15%, p=0.02).”

   Humanslate-onset multiple sclerosisn = 25

   Age-related aspects of multiple sclerosis

   Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·Jan 1, 2026

1. Late-onset multiple sclerosis is associated with fatigue in humans (63% vs 32%).

   “LOMS patients were also more frequently fatigued (63% vs 32%) and had higher fatigue severity scores (pFDR ≤ 0.033).”

   Humansin multiple sclerosis patients

   Clinical, functional and cognitive features of late-onset multiple sclerosis

   Journal of neurology·Dec 8, 2025

1. Late-onset multiple sclerosis is associated with cognitive impairment in humans (36% vs 17%).

   “Compared to AOMS, LOMS showed more frequent cognitive impairment (36% vs 17%), with worse performance in attention, verbal fluency, and global cognition (pFDR ≤ 0.049).”

   Humansin multiple sclerosis patients

   Clinical, functional and cognitive features of late-onset multiple sclerosis

   Journal of neurology·Dec 8, 2025

1. Late-onset multiple sclerosis is associated with time switching second-line treatment to the third line in humans (mean L = 65.85±45.96 m vs A = 136.13±65.75 m vs E = 171.73±83.29 m, p < 0.001).

   “time switching second-line treatment to the third line (E > L p < 0.001, A > L p = 0.002, mean E = 171.73±83.29 months-m-, A = 136.13±65.75 m, L = 65.85±45.96 m)”

   Humansin multiple sclerosis patientsn = 658

   Comparative analysis of cognitive and physical characteristics in late-onset, adult-onset and early-onset multiple sclerosis patients

   Multiple sclerosis and related disorders·Aug 6, 2024

1. Late-onset multiple sclerosis is associated with Timed 25-Foot Walk Test time in humans (mean L = 7.8 ± 6.11 vs A = 6.25±5.09 vs E = 5.72±3.13, p = 0.011).

   “participants in the LOMS group have longer T25FW (mean L = 7.8 ± 6.11, A = 6.25±5.09, E = 5.72±3.13, p = 0.011) and TUG”

   Humansin multiple sclerosis patientsn = 658

   Comparative analysis of cognitive and physical characteristics in late-onset, adult-onset and early-onset multiple sclerosis patients

   Multiple sclerosis and related disorders·Aug 6, 2024

More on Timed 25-Foot Walk Test time

1. Late-onset multiple sclerosis is associated with disability in humans (L > A > E, p < 0.001).

   “EDSS score in the first year, EDSS score in the second year (L > A > E, p < 0.001)”

   Humansin multiple sclerosis patientsn = 658

   Comparative analysis of cognitive and physical characteristics in late-onset, adult-onset and early-onset multiple sclerosis patients

   Multiple sclerosis and related disorders·Aug 6, 2024