Large granular lymphocyte leukemia

1. Phenobarbital lowers the risk of large granular lymphocyte leukemia in rats.

   “PB decreased the incidence of LGL leukemia but increased the incidence and multiplicity of hepatocellular GGT-positive foci, eosinophilic foci, and eosinophilic hepatocellular adenomas.”

   Animalsin aged F344/NCr ratsin drinking waterlivermales

   Increased susceptibility of livers of aged F344/NCr rats to the effects of phenobarbital on the incidence, morphology, and histochemistry of hepatocellular foci and neoplasms

   Journal of the National Cancer Institute·1 Oct 1983

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