Incident chronic obstructive pulmonary disease

1. Pre-COPD score predicts incident chronic obstructive pulmonary disease in humans (AUC 0.88 in CGPS, 0.76 in CCHS, and 0.81 in COPDGene).

   “The pre-COPD score is useful in predicting the onset of COPD with clinically relevant discrimination in three cohorts with different risk profiles.”

   HumansIndividuals without airflow obstruction at baseline; development in CGPS and external validation in CCHS and COPDGene5-10 years

   Risk score predicted chronic obstructive lung disease

   American journal of respiratory and critical care medicine·Nov 6, 2026

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1. C-reactive protein-albumin-lymphocyte index is associated with incident chronic obstructive pulmonary disease in humans (Fully adjusted model) (HR 0.83, 95% CI 0.81–0.85 per one-unit increment in ln-CALLY).

   “Each one-unit increment in ln-CALLY was associated with a 17% lower risk of COPD in the fully adjusted model”

   HumansFully adjusted modelOne-unit increment in ln-CALLYMean follow-up of 13.6 yearsn = 292,945

   L-Shaped Association of C-Reactive Protein-Albumin-Lymphocyte Index and COPD Incidence: A Nationwide Cohort Study in the UK Biobank

   International journal of chronic obstructive pulmonary disease·Oct 30, 2026

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