Clinical Gastroenterology and Hepatology
PRSS1 gene-linked pancreatitis tied to high pancreatic cancer risk
Pancreatic cancer risk reached 2.0% by age 50 and 5.9% by age 60 in a French nationwide cohort.Pancreatic cancer risk reached 2.0% by age 50 and 5.9% by age 60 in a French nationwide cohort.
Cohort · 455 peoplePancreatic ductal adenocarcinoma
Who was studied455 carriers of PRSS1 variants associated with hereditary pancreatitis
What changedPancreatic cancer incidence among carriers was 32.2 times the expected national rate after accounting for age and sex
The catchCancer risk estimates exclude identified carriers without follow-up