Early-onset solid cancer

1. PhenoAge is associated with early-onset solid cancer in humans (HR 1.08, 95% CI 1.03-1.13).

   “systemic aging measured by PhenoAge increased across birth cohorts, with 23% s.d. increase for those born 1965-1974 versus 1950-1954, and was associated with early-onset solid cancer risk (hazard ratio (HR)per s.d. 1.08; 95% confidence interval (CI), 1.03-1.13)”

   Humansn = 154,169

   Biological aging and generational shifts in early-onset cancer risk

   Nature medicine·Jun 22, 2026

More on PhenoAge