Acute cellular and antibody-mediated rejection

1. Immune response raises the risk of acute cellular and antibody-mediated rejection in humans.

   “In younger recipients, a large naïve T- and B-cell pool, robust thymic output, and efficient germinal centre activity confer heightened alloimmune reactivity, driving increased risk of acute cellular and antibody-mediated rejection.”

   Reviewkidney transplantation

   Immune cell subsets in young kidney transplant recipients: Mechanistic and clinical perspectives

   Transplantation reviews (Orlando, Fla.)·3 Nov 2025

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