ZhangAge

ZhangAge mediates heart disease mortality in humans (8.4% mediated).

“estimated proportions mediated of approximately 9.2 and 8.4%, respectively; however, neither remained statistically significant after Benjamini-Hochberg correction”

Humansin separate single-mediator modelsn = 502

Urinary organophosphate metabolites, DNA methylation aging, and heart disease mortality in middle-aged and older adults: an exploratory cohort study with in vitro evidence of biological plausibility

Frontiers in public health·31 Jul 2026